Dynamics of the biochemical composition of blood in first-calf cows and correlation of biochemical markers with reproductive function

Various pathologies of the breeding organs of cows are diagnosed quite often and occur due to metabolic disorders. The dynamics of the biochemical composition of blood in first -calf cows (n=24) during lactation was studied, and the correlation of separate biochemical markers with fertilization was determined. It was found that after calving, a qualitative redistribution of plasma proteins occurs in animals, characterized by a decrease in the albumin-globulin coefficient by 29.0...43.2%, a drop in creatinine level by 40.9% by the third month of lactation, and then its increase by 27.9...35.3%.The urea concentration doubles by the 90th day after calving, followed by a decrease of 33.8% by the seventh month. The activity of AlAT and AsAT increases in the first three months after childbirth (by 1.9 times and by 23.7%, respectively), and decreases by the time of launch. The de RiTiS coefficient was the highest in heifers and cows at the time of launch (4.49 and 3.95 units, respectively), and the lowest on the 60-90 day of lactation (2.81...2.98 units).The amount of total immunoglobulins after childbirth decreased, and reached minimum values by the 5th month of lactation (103.8 mg/l). Circulating immune complexes (CEC) of large and small size reached a peak concentration by the seventh month of the studies (94.7 and 176.7 UE / l, respectively), and their ratio was characterized by the predominance of more pathogenic small-sized cells at the 2nd month of lactation, followed by their enlargement. The concentration of substances of medium and low molecular weight (VSNMM) in red blood cells was maximum at the 3rd month after delivery (33.7 opt. units), then their level decreased. Correlation analysis showed that the duration from calving to fertilization lengthens with an increase in the de Ritis effect (r=0.441...0.513) and the concentration of VSNMM in red blood cells (r=0.336...0.438), turns over with an increase in AlAT activity (r=-0.325...-0.446). 

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