Clinical and morphological substantiation of the comparative effectiveness of the use of antibacterial drugs based on cefapirin in subclinical endometritis in cows

The article presents information on the prevalence of subclinical endometritis in cows, which were carried out on the basis of ZAO breeding farm "Povadino", as well as morphological changes in the mucous membrane of the uterus in this pathology. On the basis of the diagnosis, the animals were treated using various schemes with antibacterial drugs based on cefapirin. The studies were carried out on the basis of the Department of Anatomy and Histology of Animals named after Professor A.F. Klimov FGBOU VO MGAVMiB - MBA named after K.I. Scriabin, as well as at ZAO Povadino breeding plant, cytomorphological studies were carried out on the basis of the Chance Bio laboratory in the period from 2019-2021. According to the principle of analogs, 3 groups of animals with the manifestation of subclinical endometritis (15 animals in each) were formed. The animals of the first (experimental) group were injected with the drug "Mitrek"; the animals of the second (comparative) group - the drug "Metrikur", the animals of the third (control) group were injected with the drug "Tylosinocar" intrauterinely, according to the instructions. A comprehensive methodological approach was used, including clinical examination of animals, fine anatomical preparation, cytomorphological examination of cervical mucus, statistical analysis of the obtained digital data, light microscopy of histological sections stained by the classical technique with hematoxylin and eosin. To determine the extent and etiology of postpartum endometritis in black-and-white Holsteinized cows, obstetric-gynecological clinical examination was carried out, which was carried out according to the generally accepted method. In addition to general clinical methods for diagnosing this pathology, cytomorphological studies of 120 smears of cervical mucus were carried out to objectify the diagnosis. Based on the results of a comprehensive study aimed at identifying subclinical endometritis, it was found that this pathology is observed in 53.55% of the studied animals, macro- and morphological changes in the uterus with subclinical endometritis were revealed. endometrium, due to the influence of pathogenic microflora: Staphilococcus aureus, Escherichia coli, Streptococcus viridans group. And also, based on the results of the studies performed, a comparative assessment of the therapeutic efficacy of drugs based on cefapirin was carried out.

1. Белякова, А.П. Морфометрические показатели матки коров черно-пестрой голштинизированной породы в норме и при субклиническом эндометрите / Белякова А.П., Слесаренко Н.А., Широкова Е.О. // Ветеринария, зоотехния и биотехнология. 2020. – № 12. – С. 36-42.

2. Кашковская, Л.М. Оптимизация терапии коров при эндометритах / Л.М. Кашковская, А.В. Балышев, С.В. Абрамов // Ветеринария. 2020. – № 5. – С. 44-47.

3. Коба, И.С. Сравнение схем профилактики эндометритов у коров с применением антибиотиков и пробиотиков / И.С. Коба, Е.Н. Новикова // Ветеринарный фармакологический вестник. 2019. – № 1 (6). – С. 19-24.

4. Коба, И.С. Клиническая картина и гистологические изменения при хроническом эндометрите у коров / И.С. Коба, М.С. Дубовикова, Е.Н. Новикова // Ученые записки Казанской государственной академии ветеринарной медицины им. Н.Э. Баумана. 2019. –Т. 239. – № 3. –С. 141-144.

5. Методология научного исследования / H.A. Слесаренко и [др.]; под ред. H.A. Слесаренко. - СПб.: Лань, 2018. – 268 с.

6. Семиволос, А.М. Рациональные методы терапии коров при остром послеродовом гнойно-катаральном эндометрите / А.М. Семиволос, А.А. Брюханова // Аграрный научный журнал. 2021. – № 2. – С. 64-67.

7. Слесаренко, Н.А. Хронические эндометриты у коров: новый подход в терапии / Н.А. Слесаренко, Е.О. Широкова, Л.М. Кашковская // Ветеринария. 2019. – № 1. – С. 41-45.

8. Скориков, В.Н. Цитологический состав цервикальной слизи у коров с острым послеродовым эндометритом / В.Н. Скориков, Е.В. Михайлов, Б.В. Шабунин // Ветеринарный фармакологический вестник. 2020. – № 3 (12). – С. 156-163.

9. Щипакин, М.В. Анатомия органов репродукции овцы романовской породы / М.В. Щипакин, С.А. Куга, Д.С. Былинская, С.В. Вирунен // Иппология и ветеринария. 2016. – № 1 (19). – С. 133-137.