Eficiency of aminoglycoside antibiotics cryptosporidiosis of calfs

Abstract

The effectiveness of aminoglycoside antibiotics, paromomycin, for cryptosporidiosis in calves was determined based on the results of a coprological study and an assessment of the physiological state before and after the treatment of the animals. Calves with signs of diarrhea, dehydration, cachexia, and were later diagnosed with cryptosporidiosis, were given the drug «Protostop» orally, containing 100,0 mg of paromomycin sulfate in 1,0 g. The animals were separated into 5 groups, 10 calves in each: four experimental and one control. Animals from groups № 1 and № 2 were given the drug «Protostop» orally, at a dose of 250 mg per 1 kg of the animal’s weight, in a course of 3 and 5 days, respectively. The animals in groups № 3 and № 5, the drug «Protostop» was given orally at a dose of 350 mg per 1 kg of the animal’s weight, in a course of 3 and 5 days, respectively. Calves in the control group (№ 5) underwent therapy with an analogue drug, «Parofor 70». After administration of the drug «Protostop» orally with liquid for 3 days at a dose of 250 mg per1 kg of the animal’s weight (group №1), as well as at a dose of 350 mg per 1 kg (group № 2), significant improvements were noted, which confirmed the results of scatological studies, but Cryptosporidium oocysts continued to stand out. Cryptosporidium oocysts were not detected, after the introduction of the oral drug «Protostop» for 5 days at a dose of 350 mg per 1 kg of animal weight (group № 4). In samples of feces from calves of the control group (№ 5), which received therapy with the drug «Parofor 70», single oocysts of Cryptosporidium werefound after a 5-day course of treatment.