Experimental study of the biocompatibility of the implant based on bacterial cellulose

This work is devoted to an experimental study of the reaction of body tissues to an implant based on bacterial cellulose synthesized by the bacterial strain Gluconacetobacter xylinus. The influence of the internal environment of the body on the characteristics of the implanted material was also studied to determine the prospects for its use in veterinary medicine.
Currently, the issue of creating new implantable materials for a long time, or improving existing ones, does not lose its relevance. Based on this, it can be concluded that there are shortcomings in the previously developed materials. Certain requirements are imposed on implantable materials, such as elasticity, strength, porosity, non-toxicity, and others. The most important property of such materials can be called biocompatibility, as well as resistance to the effects of the biological environment.
This study is aimed at establishing the possibility of using bacterial cellulose (BC) as an implantable material, which combines all the necessary properties for implants. The study of the reaction of body tissues to the implant was carried out on laboratory rats of the Wistar line. The implanted material was placed on the outer layer of the muscles of the abdominal wall of laboratory animals, after which, on the 14th, 30th and 90th days, a visual examination of the state of cellulose and nearby tissues was carried out, and tissues were selected for histological examination.
The experimental results indicate that the implant based on bacterial cellulose does not cause negative reactions from nearby tissues, does not collapse during the observation period, and is reliably fixed on the muscle layer by a capsule of collagen fibers.

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