Bile acids as a diagnostic indicator of the state of homeostasis: a systematic descriptive analysis
https://doi.org/10.52419/issn2072-2419.2022.1.52
Abstract
Diseases of the hepatobiliary system occupy a leading position among diseases of non-contagious etiology in animals. Hepatopathy of various origins cause significant economic damage to livestock farms due to a decrease in overall resistance, a decrease in productivity, as well as an increase in the cost of both therapeutic and preventive measures. The prerequisites for an increase in the number of cases of such diseases are mainly violations of the conditions of keeping and feeding animals.
Bile acids are increasingly being evaluated as complex metabolic integrators and signaling factors for various metabolic disorders. Increased attention to bile acids as metabolic regulators has led to two main research questions: how do bile acid dominants change in metabolic diseases and how can the activity of bile acids be used to treat metabolic diseases? Both issues will be addressed in this review. We searched for original studies in the scientific databases PubMed, Elsevier Science (Scopus) and Clarivate Analytics (Web of Science) to identify the biochemical, signaling and target functions of bile acids, after which a formalized content analysis of the found publications was carried out. In recent years, much attention has been paid to bile acids, not only as the end products of cholesterol metabolism and the main components of bile, but also their role in a number of pathological conditions of the body. Thus, the data obtained by various researchers show that they can be markers of differential diagnosis between hepatopathy of various origins, which makes them one of the most promising diagnostic models.
Supporting agencies: The work was supported by the Russian Science Foundation (project no. 22-26-00158).
About the Authors
Yu. E. Kuznetsov
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
doctor of vet. Sci., Associate Professor department of parasitology named after V.L. Yakimov
A. M. Lunegov
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
Ph.D. Sciences, Associate Professor, Head. department pharmacology and toxicology
V. S. Ponamarev
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
assistant of the Department of Pharmacology and Toxicology
E. B. Romashova
St. Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
PhD student parasitology department of parasitology named after V.L. Yakimov
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Review
For citations:
Kuznetsov Yu.E., Lunegov A.M., Ponamarev V.S., Romashova E.B. Bile acids as a diagnostic indicator of the state of homeostasis: a systematic descriptive analysis. International Journal of Veterinary Medicine. 2022;(1):52-56. (In Russ.) https://doi.org/10.52419/issn2072-2419.2022.1.52
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