Correlative relations of malnutrition and redox homeostasis disorders in allergic enteropathy in dogs with severe gi syndrome

Abstract

Malnutrition syndrome is widespread in allergic enteropathy in dogs, causing a violation of absorption and transport of nutrient substrates in the intestinal mucosa, which serves as a trigger for subsequent metabolic changes in the gastrointestinal system, affecting hepatocytes through the activation of lipid peroxidation processes and the development of shifts in the redex system. homeostasis. As a result of biochemical and morphological studies of the blood of sick animals with allergic enteropathy with severe gastrointestinal syndrome, a violation of metabolic processes was established (T-Pro - 59.46±0.32 g/l and 63.34±0.53 g/l; ALB - 19.71±0.64 g/l and 18.56±0.50 g/l; GLB - 39.75±0.82 g/l and 44.78±0.96 g/l; A/G - 0.49±0.06 and 0.41±0.08; RBC - 5.85±0.17×1012/l and 5.67±0.16×1012/l; Na - 134.50±6.10 mmol/l and 130.80±5.97 mmol/l, K - 3.43±0.10 mmol/l and 3.40±0.09 mmol/l, Ca - 2.15±0.07 mmol/l and 2.13±0.06 mmol/l), redox homeostasis (ALT - 108.95±11.00 U/l and 115.73±9.39 U/l; AST - 62.90±6.05 U/l and 60.30±5.80 U/l; ALP - 196.05±19.20 U/l and 210.20±23.91U/l) due to activation of lipid peroxidation processes (MDA - 23.10±1.06 µmol/ml and 24.25±1.40 µmol/ml; DK - 1.08±0.15 uA/ml and 1.15±0.09 uA/ml) and antioxidant potential depletion (CT - 0.54±0.02 Bach units and 0.55±0.03 Bach units; SOD - 18.23±1.59 EU/mg protein per minute and 19.98±1.91 EU/mg protein per minute; GSH-Px - 26.69±2.46 µmol/ml and 28.31±3.02 µmol/ml; Vitamin A - 0.66±0.05 mcg/ml and 0.59±0.03 mcg/m; Vitamin E - 8.49±0.90 mcg/ml and 7.87±0.98 mcg/ml). The presence of direct correlations between the level of trophological disorders due to the development of intestinal malabsorption syndrome and the degree of redox homeostasis disorders was revealed.