Influence of boar castration on the background of immunocorrection on the pigment, enzyme and lipid metabolism

The article presents data on the effect of castration on changes in indicators reflecting pigment, enzyme and lipid metabolism. The experiments were carried out on 14 boars (aged 5 month), divided into two groups ‒ control and experimental (n=7 in each).
Medical support before castration (using an open method) consisted of an intramuscular injection of ketoject, and during the post surgery period ‒ in the repeated use of the abovementioned drug, as well as cobactan and hipratopic spray. The boars of the experimental group were additionally injected with thymogen, which is a synthetic analogue of one of the thymus hormones.
Blood sampling was performed before the surgery, as well as on the 14th and 30th day after it; serum was obtained by the conventional method. The content of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total and direct bilirubins, cholesterol, triglyceride, lactate dehydrogenase, α -amylase, γ-glutamyltransferase were determined and the de Ritis coefficient was calculated.
It was found that castration in both the control and experimental groups (against the background of immunocorrection) caused significant changes in the biochemical status of animals in both groups, in most cases having the same pattern. Thus, on the 14th day, 9 out of 10 indicators were characterized by negative dynamics, and on the 30th ‒ by positive, in five cases of which they exceeded the level of the pre-surgery period. Only in relation to triglycerides, an upward trend
was noted at all stages of the studies. The de Ritis coefficient was diverse.
The most pronounced changes were recorded at the catabolic phase in the enzymatic system of indicators ‒ aminotransferases (especially ALT, γ-glutamyltransferase, lactate dehydrogenase, α-amylase). The anabolic phase is characterized by the normalization of indicators of AST, alkaline phosphatase, γ-glutamyl transferase, lactate dehydrogenase; below the initial, but exceeding the standard values ‒ AlAT; upper limit of reference intervals ‒ total bilirubin, cholesterol, triglycerides.
The use of thymogen significantly reduced the negative impact of surgery, especially at the catabolic phase, and contributed to a more rapid normalization of indicators reflecting enzyme metabolism. Their dynamics in the experimental group was characterized by a smaller amplitude and intervals in the min – max range compared to the control group. At the catabolic phase (in most cases), there were no significant differences in the dynamics of lipid and pigment metabolism between the groups (against the background of reference values); at anabolic phase – an increase in the level of total bilirubin, cholesterol and triglycerides.

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