CRITERIA IN THE PROGNOSTIC OF GENERALIZATION OF BACTERIOSES IN DOGS WITH UTERINE INFLAMMATION
https://doi.org/10.52419/issn2072-2419.2022.3.11
Abstract
A common complication in purulent endometritis is septicemia and septic shock, leading to the death of the animal. To prevent the development of complications, an early diagnosis is carried out. For this purpose, a proprietary variation of the scoring models (scales PRO (P = predisposition, I = infection, K = response, O = organ dysfunction) and PYOMETRA) is proposed. An algorithm of actions has been developed for making operational decisions on the prognosis of possible septic complications in animals, including an assessment of the clinical manifestation of the inflammatory response SIRS, the syndrome of multiple organ insufficiency MODS and the syndrome of compensatory anti-inflammatory response CARS. The algorithm at the first stage provides for the determination of the PIRO score. If necessary, if the PIRO data indicate a doubtful, cautious or unfavorable prognosis, an assessment of the cellular and humoral blood parameters of dogs is carried out on a PIOMETRA scale. This makes it possible to determine the degree of development of the clinical manifestation of the inflammatory response (SIRS) and the level of expenditure of the body's protective resources because of the anti-inflammatory response (CARS). The indicator of the severity of the general condition of the sick animal also affects the reliability of the prognosis regarding the outcome of the disease. When evaluating the PIRO and PYOMETRA scales in the study, some animals had a mild degree; others had a medium, severe or critical degree of severity of the disease, which allowed us to confirm the importance of using additional scales when developing strategies and tactics for treating animals.
About the Authors
N. V. Pimenov
Federal State Budgetary Educational Institution of Higher Education «Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K. I. Skryabin»
Russian Federation
Russian Federation
Professor of the Department of Immunology and Biotechnology, Doctor of Biological Sciences
S. V. Laptev
Federal State Budgetary Educational Institution of Higher Education «Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K. I. Skryabin»
Russian Federation
Russian Federation
Associate Professor of the Department of Immunology and Biotechnology, Candidate of Biological Sciences
K. Yu. Permyakova
Federal State Budgetary Educational Institution of Higher Education «Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K. I. Skryabin»
Russian Federation
Russian Federation
Senior lecturer of the Department of Immunology and Biotechnology
R. F. Ivannikova
Federal State Budgetary Educational Institution of Higher Education «Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K. I. Skryabin»
Russian Federation
Russian Federation
Associate Professor of the Department of Physiology, Pharmacology and Toxicology, Candidate of Biological Sciences
S. N. Mazanova
Federal State Budgetary Educational Institution of Higher Education «Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K. I. Skryabin»
Russian Federation
Russian Federation
Associate Professor of the Department of Immunology and Biotechnology, Candidate of Biological Sciences
References
1. Blendinger K., Bostedt H. Zum Alter und ZyklusstadiumbeiHundinenmitPyometra // Tierarztl. Prax. – 1991 – Vol. 19 – Pp. 307– 310.
2. De Schepper J. The characteristic pattern of aspartate aminotransferase and alanine aminotransferase in the bitch with the cystic hyperplasiapyometra complex: effect of medical or surgical treatment / J. De Schepper J. Van der Stock E. Capiau // Vet. Res. Com. - 1987. - Vol. 11. - P. 65-75.
3. Fransson B. Systemic Inflammatory Response in Canine Pyometra: The Response to Bacterial Uterine Infection. Doctoral Thesis (Veterinaria) Swedish University of Agricultural Sciences, Uppsala, 2003. - 49 p.
4. Gibson A. Retrospective study of pyometra at five RSPCA hospitals in the UK:1728 cases from 2006 to 2011/ A. Gibson R. Dean D. Yates J. Stavisky // Vet. Rec. – 2013 – Vol. 173(16). – P. 396
5. Hauptman J.V. Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs / J.V. Hauptman R. Walshaw N.B. Olivier // Vet. Surg. - 1997. -Vol. 26. - P. 393-397.
6. Jitpean S. Predictive Markers and Risk Factors in Canine Pyometra. Doctoral Thesis Swedish University of Agricultural Sciences. Uppsala, 2015. - 73 p.
7. Kozak, W. Role of cytochrome P-450 in endogenous antipyresis / W. Kozak [et al.] // Am. J. Physiol. Regulatory Integrative Comp. Physiol. L. – 2000. – V. 279. – P. R455–R460.
8. Mackowiak, P.A. Temperature regulation and the pathogenesis of fever / P.A. Mackowiak; ed. by L. Gerald [et al.] // Man-dell, Douglas, and Bennett’s principles and practice of infectious diseases. – 2010. – V. 1. – P. 765–778.
9. Netea, M. G. Circulating Cytokines as Mediators of Fever / M.G. Netea, B.J. Kullberg, J.W.M. Van der Meer // Clin. Infect. Dis. – 2000. – V. 31, Suppl. 5. – P. S178– S184.
10. Niskanen M., Thrusfield M.V. Associations between age, parity, hormonal therapy and breed, and pyometra in Finnish dogs 1998// Vet. Rec. – 1998 – Vol. 143 –P. 493– 498.
11. Oelzner J., Munnich A. Diagnosis and treatment of the endometritispyometracomplex in the bitch // Tierarzt. Prax. - 1997. - Vol. 25(3). - P. 249-253.
12. Oka, T. Mechanisms and Mediators of Psychological Stress-Induced Rise in Core Temperature / T. Oka [et al.] // Psychosomatic Medicine. – 2001. – V. 63 – P. 476– 486.
13. Sant'AnnaM.C. Prognostic markers of canine pyometra / M.C. Sant'Anna L.G.P. Giordano K.K.M.C. Flaiban et al. // Arq. Bras. Med. Vet. Zootec. - 2014. - Vol. 66 (6). - P. 1711-1717.
14. Sevelius E. Pyometra in the dog / E. Sevelius A. Tidholm T.K. Thoren // J. Am. Anim. Hosp. Ass. - 1990. - Vol. 26. - P. 33-38.
15. Stone E.A. Renal dysfunction in dogs with pyometra / E.A. Stone M.P. Littman J.L Robertson K.C Bovee // J. Am. Vet. Med. Ass. – 2008. – 198 57.
16. Van Deuren, M. Differential expression of proinflammatory cytokines and their inhibitors during the course of menin- gococcal infections / M. Van Deuren [et al.] // J. Infect. Dis. – 1994. – V. 169. – P. 157– l61.
17. Verstegen J. Mucometra, cystic endometrial hyperplasia, and pyome-tra in the bitch: Advances in treatment and assessment of future reproductive success / J. Verstegen G. Dhaliwal K. Verstegen-Onclin // Theriogenology. - 2008. - Vol. 70(3). -P. 364-374. http://doi.org/10.1016lj.theriogenology.2008.04.036
18. Лаптев С.В. Организация учебносличительного прогноза гнойносептических осложнений при панлейкопении кошек методом бальной оценки показателей PIRO. Товароведение, технология и экспертиза: инновационные решения и перспективы развития» // Мат. II национальной научно-практической конференции «Товароведение, технология и экспертиза: инновационные решения и перспективы развития» – 01 июня 2021 г. – М.: ФГБОУ ВО МГАВМиБ – МВА имени К.И. Скрябина, 2021. – 319-327
19. Лаптев С.В., Мезенцева Н.И. Клеточные и гуморальные механизмы защиты при коронавирусной инфекции. Справочник заведующего КДЛ. № 5. 2021. С. 12-23.
20. Мещерякова, Е.А. Сигнальные клеточные пути и белковые взаимодействия, индуцированные мурамоилпептидами / Е.А. Мещерякова, Т.М. Андронова, В.Т. Иванов // Биоорганическая химия. – 2010. – Т. 36, No 5. – С. 581–595.
21. Шанин, В.Ю. Лихорадка и реакция острой фазы / В.Ю. Шанин // Патофизиология. – СПб.: ЭЛБИ-СПб, 2005. – Гл. 7. – С. 116–123.
Review
For citations:
Pimenov N.V., Laptev S.V., Permyakova K.Yu., Ivannikova R.F., Mazanova S.N. CRITERIA IN THE PROGNOSTIC OF GENERALIZATION OF BACTERIOSES IN DOGS WITH UTERINE INFLAMMATION. International Journal of Veterinary Medicine. 2022;(3):11-21. (In Russ.) https://doi.org/10.52419/issn2072-2419.2022.3.11
Views:
457
Email this article 