REGENERATIVE PROCESSES IN THE RENAL BODIES AFTER PRIVATE NEPHRECTOMY WITH THE USE OF THE ALLOPLANT SUTURE FOR SEWING

Abstract

To date, the study of the process of cell proliferation in organs and tissues, as well as the possibility of its stimulation is very important in many types of pathology. Primary damage to somatic cell types in the glomerular apparatus of the kidneys is associated with various pathologies. Damaged endothelial and mesangial cells are restored due to the proliferation of neighboring cells. To study the reparative processes in the renal corpuscles, the change in the number of Ki-67+ cells was assessed. Ki-67 is expressed in the cell nucleus at all stages of the cell cycle, except for G0. Therefore, the number of Ki-67+ cells reflect proliferative activity. The search for new ways to stimulate organ regeneration and methods for its evaluation is an important direction. When evaluating the Ki -67 protein in the cells of the renal corpuscles, three types of expression are distinguished: granular, diffuse, and granular-diffuse. We found that an increased (by 40.21%) number of Ki-67+ cells in the damaged area on the 3rd day indicates active regeneration processes, then from the 6th day the values of this parameter decrease, but still remain higher. than during surgery. We associate such dynamics of changes in the studied parameter with alteration and active inflammatory processes localized in this zone. In the zone without damage, we noted a wave-like dynamics of changes in the number of Ki-67+ cells in the renal corpuscles in the zone without damage with 2 periods of increase (on the 3rd and 18th days) and a decrease to the values obtained during the operation by 60 -m days. We believe that this indicates an early (3rd day) regenerative activity of cells, as well as the process of tissue remodeling. Our results can help improve the diagnosis and treatment of animals with kidney pathologies.