Pre-clinical study of complex phytosorbents on the basis of makley and chitozan

Abstract

The aim of our research was to assess the toxicity of complex phytosorbents based on maklea cordate and chitosan. Evaluation of antimicrobial activity in vitro was carried out according to the General Pharmacopoeia Monograph (the method is described in the Pharmacopoeia (OFS.1.2.4.0010.15), three types of phytosorption complex were used as the material for the study. Phytosorbents were included in samples 1-3. In addition to sorbents, sample No. 1, oil of oregano and thyme containing carvacrol (with proven antimicrobial activity in previous experiments) was added, compound Macleaya cordata was added to compound No. 2, and chitosan was added to compound No. 3-components of samples 1. He study of the toxicity of the studied parameters was studied according to the guidelines [5]. The hazard class of the studied drugs was determined according to GOST 12.1.007-76. According to experiments, drugs can be classified as low-hazard substances. Assessment of acute and subacute toxicity proved the absence of negative effects of both drugs on the body of laboratory animals, at a dose twice and four times the recommended therapeutic, which is 6000 mg / goal. and 12000 mg / goal., Do not cause toxic effects and death of animals. And the introduction of complexes with chitosan and macklea, at a dose of 6000 mg / goal. within 28 days, positively affects the body of laboratory rats. That allows research to determine the effectiveness, including on productive animals. Factors that determine the relevance of the development of highly effective phytobiotics and their use in animal husbandry and poultry farming should also include the high profitability of the production of environmentally friendly agricultural products and the task of improving the quality of life of the population.