Application biopolymer dosage form with plant extracts

Abstract

The development of the pharmaceutical industry is directly related to changing working conditions in industrial complexes. Intensification of production increases not only animal productivity, but also labor productivity. Therefore, the use of drugs in animal husbandry should be convenient, simple and prolonged. For this purpose, a formulation of an application dosage form based on biopolymers has been developed, with the addition of herbal extracts, which has a viscousplastic, homogeneous consistency, with uniform distribution and adsorption on the skin, without adhesion to the skin and the ability to release the active substance by the polymer composition over a specified time. Application dosage forms are able to maintain a constant concentration of the active substance (AS) at the site of application for a long time, creating high concentrations of AS in cells. To develop this dosage form, experiments were conducted with various polymers (gelatin, starch, agar-agar) and dry extracts of medicinal plants. As a result, it was established that the most optimal components of the application dosage form are a combination of gelatin, starch, dry extracts of marshmallow root, oak bark. Bioavailability of the application dosage form was assessed by the kinetics of diffusion of active components into agar, by recording the cross -sectional distribution at temperatures of 25̊C and 37̊C. The degree of release of the active components of the application dosage form was judged by the diameter of the colored zones, which were measured after 1, 2, 3 and 4 hours. As a result of studies of the possibility of releasing the active substance from the polymer composition, smooth diffusion of the active substance from the application dosage form by cross-sectional distribution and the level of penetration into agar over time was established. Medicinal herbs in this composition act as biologically active substances, and are also formative components.