Features of the elimination of exogenous sorbitol in cattle
https://doi.org/10.52419/issn2072-2419.2025.3.548
Abstract
The article presents the results of a study of the kinetics of elimination of exogenous sorbitol in urine in clinically healthy cattle animals. Time intervals and quantitative indicators of drug elimination have been established, which is the fundamental basis for the development of a sorbitol tolerance test as a predictor of the functional state of the hepatobiliary system. The results of the work fill the existing gap in data on the metabolism of sugar alcohols in ruminants. The features of the pre-pancreas of cattle inhabited by microbiota capable of fermenting various carbohydrates and sugar alcohols can theoretically influence the absorption processes and subsequent kinetics of sorbitol. However, there is practically no data on the elimination of exogenous sorbitol in cattle in available scientific sources. In connection with the above, the purpose of this study was to study the characteristics of the elimination of orally administered exogenous sorbitol in cattle with an assessment of its urinary excretion to justify further use as a stress test to assess the state of the hepatobiliary system. The results obtained demonstrate that in healthy cattle, exogenous sorbitol begins to be detected in the urine 2 hours after administration, reaches a peak concentration by 4- 6 hours, and is almost completely eliminated within 24 hours. An important conclusion is the presence of statistically significant differences in the level of sorbitol excretion between groups of animals differing in sex, age, physiological status and type of feeding. The observed differences, in particular, higher excretion in bulls compared to heifers and cows, as well as in cows on a highconcentration diet compared to their counterparts on a standard diet, suggest that not only liver function, but also features of cicatricial digestion, hormonal status and metabolic rate can affect sorbitol metabolism in ruminants. This indicates the need to take these factors into account when interpreting load tests.
Keywords
Supporting agencies: The study was funded by the Russian Science Foundation under the research project No. 24-26-00005 (https://rscf.ru/project/24-26-00005/).
About the Authors
V. S. Ponamarev
Saint Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
PhD in Veterinary Medicine, Associate Professor at the Department of Pharmacology and Toxicology
P. S. Pogodaeva
Saint Petersburg State University of Veterinary Medicine
Russian Federation
Russian Federation
PhD in Veterinary Medicine, Associate Professor at the Department of Biochemistry and Physiology
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Review
For citations:
Ponamarev V.S., Pogodaeva P.S. Features of the elimination of exogenous sorbitol in cattle. International Journal of Veterinary Medicine. 2025;(3):548-554. (In Russ.) https://doi.org/10.52419/issn2072-2419.2025.3.548
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