The results of studying the tolerability of the drug "Endoseptam"

The fight against obstetric and gynecological diseases in cattle, in particular endometritis, is an important link in the system of measures for the improvement of livestock. At the same time, the development of effective complex means and methods of treatment and prevention of endometritis is an urgent task of veterinary medicine. The study of animal tolerance of the target species and the identification of a set of morphological and functional disorders in the use of newly created drugs is an integral part of the preclinical study of drugs and allows us to conclude that further laboratory and industrial tests can be performed. This article presents results of studying the tolerability of the original drug «Endoseptam» for the treatment and prevention of obstetric and gynecological diseases in cattle experiments. The studies included conventional clinical, hematological, and microbiological methods. To conduct the experiments, three groups of healthy lactating cows were formed, with 6 animals in each: the first served as a control, the cows of the second group were intrauterinely injected with the drug "Endoseptam" in a therapeutic dose (100 ml four times with an interval of 24 hours), the animals of the groups were injected with the drug in a dose of 300 ml four times with an interval of 24 hours. It was found that when using the drug «Endoseptam» at a therapeutic dose and three times its maximum, there was no negative effect on the body, in particular morphological and functional disorders, thus «Endoseptam» has no general toxic effect, is safe and well tolerated by animals of the target species.

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