Functional state of the antioxidant system in sows with lithium ascorbate supplementation
https://doi.org/10.52419/issn2072-2419.2026.1.178
Abstract
One of the key physiological factors determining the success of reproduction is the oxidative status of the body, since during gestation, farrowing and location, the level of metabolic stress in sows increases, accompanied by increased formation of free radicals. The aim of the study was to comprehensively evaluate the effectiveness of lithium ascorbate in modulating the antioxidant system of sows during gestation. For this purpose, an experiment was conducted on clinically healthy sows, which were divided into two groups: control and experimental. The animals in the experimental group were given lithium ascorbate orally at a dose of 10 mg/kg body weight per day throughout the entire reproductive cycle, including the service period, gestation, and lactation. The control group did not receive any supplement. To assess the antioxidant status, blood samples were collected from the sows on days 30 and 110 of gestation to measure the concentrations of glutathione (GSH and GSSG), calculate the thioldisulfide ratio (GSH/GSSG), and determine the level of malondialdehyde (MDA). It has been established that the use of lithium ascorbate causes statistically significant changes in indicators of oxidativeantioxidant homeostasis in pregnant sows. In the experimental group, there was an increase in glutathione (GSH) levels and a decrease in glutathione disulfide (GSSG) content, leading to an improvement in the GSH/GSSG ratio compared to the control group. Additionally, a reduction in malondialdehyde (MDA) concentration was observed. The positive effects were more pronounced on day 110 of gestation, which corresponds to the period of maximum physiological stress. The results suggest that lithium ascorbate has antioxidant activity in sows during pregnancy, possibly through activation of the glutathione system and inhibition of lipid peroxidation. These findings support the potential use of lithium ascorbate in feeding schemes to prevent oxidative stress and support the reproductive health of sows in conditions of increased physiological and environmental stress.
Supporting agencies: The work was carried out with the financial support of the Ministry of Education and Science, project №. 124020200032-4.
About the Author
I. V. Kutyin
Institute of Animal Physiology, Biochemistry and Nutrition,
branch of the Federal Research Center of Animal Husbandry, Ernst VIZh
Russian Federation
Russian Federation
researcher of the laboratory of immunobiotechnology and microbiology
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For citations:
Kutyin I.V. Functional state of the antioxidant system in sows with lithium ascorbate supplementation. International Journal of Veterinary Medicine. 2026;(1):178-184. (In Russ.) https://doi.org/10.52419/issn2072-2419.2026.1.178
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