Hematological parameters of ducklings' blood when using ciprofloxacin in conditions of experimental staphylococcal infection

The purpose of this work is to study the hematological parameters of ducklings' blood in conditions of experimental Staphylococcosis, using the chemotherapeutic drug ciprofloxacin, which has a wide spectrum of action. Ciprofloxacin has a more active effect on aerobic gram-negative bacteria, as well as on staphylococci. To conduct the study, three groups of ducklings were formed (I – control, II and III – experimental). Experimental infection of ducklings of groups II and III with Staphylococcus aureus culture was carried out. The day before and for four days after infection, ducklings of group III received ciprofloxacin at a dose of 200 mg/l together with water. Blood sampling from all experimental birds was carried out on the first, third, sixth, ninth and thirteenth days after infection. The parameters of the erythron system, as well as the number of leukocytes and the leukocyte formula, were studied, and the leukocyte indices were calculated. The research results indicate a positive effect of ciprofloxacin on ducklings in experimental staphylococcal infection. The recorded changes in red blood counts were reversible, short-term, and did not adversely affect the ducklings' physiological condition. As a result of the analysis of the data obtained, statistically significant changes in white blood parameters in groups II and III were noted relative to the control group. Experimental infection caused shortterm leukocytosis, which manifested itself in all experimental groups. The presence of an inflammatory reaction was found, characterized by a significant increase in the absolute number of pseudoeosinophils and monocytes in groups II and III in comparison with the control. Nevertheless, the hematological parameters of blood in group III were relatively closer to those of the control group. Dynamic shifts in the indices of nonspecific reactivity and endogenous intoxication are most informative and prolonged in experimentally infected ducklings that did not receive ciprofloxacin.

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