Pathomorphological picture of anaphylactic drug shock in piglets caused by iron preparations
https://doi.org/10.52419/issn2072-2419.2026.1.261
Abstract
This study presents the results of a postmortem examination of three 4-day-old piglet carcasses that died following the intramuscular administration of the ironcontaining drug Erytrofer 200 at a preventive dose of 1 ml. The aim of the research is to draw the attention of veterinary specialists to the problem of postmortem diagnosis of drug-induced anaphylactic shock caused by the parenteral administration of iron preparations. The materials were based on protocols of forensic veterinary examinations of three cases of drug-induced anaphylactic shock with lethal outcomes. During the autopsy, the following pathological diagnoses were established: staining of surrounding tissues, edema and focal necrosis of muscles at the injection site; staining of regional lymph nodes; myocardial dystrophy ("paralytic heart"); acute congestive hyperemia of the membranes and cerebral edema; acute congestive hyperemia and pulmonary edema; edema of the subcutaneous tissue, lymph nodes, and mesentery of the large intestine; acute congestive hyperemia of the liver and spleen; edema and protein degeneration of the kidneys; petechial hemorrhages on the serous membrane of the colon and the renal cortex; anemia of the mucous membranes and muscle tissue. It was determined that the death of the animals occurred due to anaphylactic shock induced by the administration of the iron-containing drug. The immediate cause of death was cardiac paralysis resulting from acute heart failure and hypoxic conditions, exacerbated by cerebral and pulmonary edema. The injection site in the neck region contributed to the development of a hyperergic inflammatory reaction with edema of the surrounding tissues.
The research materials include descriptions of the gross pathology of the external integuments and internal organs. The paper presents photographs of the piglets' organs with pathological changes characteristic of drug-induced anaphylactic shock provoked by the use of Erytrofer 200.
About the Authors
M. V. Koshkarev
Omsk State Agrarian University named after. P.A. Stolypin
Russian Federation
Russian Federation
Candidate of Veterinary Sciences, Associate Professor of the Department of Anatomy, Physiology, Histology and Pathological Anatomy
T. V. Boyko
Omsk State Agrarian University named after. P.A. Stolypin
Russian Federation
Russian Federation
Doctor of Veterinary Sciences, Associate Professor, Head of the Department of Diagnostics, Internal Non–infectious Diseases, Pharmacology, Surgery and Obstetrics
A. S. Lyubimova
Omsk State Agrarian University named after. P.A. Stolypin
Russian Federation
Russian Federation
asp.
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Review
For citations:
Koshkarev M.V., Boyko T.V., Lyubimova A.S. Pathomorphological picture of anaphylactic drug shock in piglets caused by iron preparations. International Journal of Veterinary Medicine. 2026;(1):261-274. (In Russ.) https://doi.org/10.52419/issn2072-2419.2026.1.261
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