Comparative evaluation of leukocytic indices in inflammation of glandular and connective tissues in animals with lymphocytic blood profile

Inflammation is a typical pathological process that plays an important role in protecting the body, but the course of the process can vary significantly depending on the type of tissue and individual characteristics of the animal, including the blood profile, which is key in determining the nature and intensity of the inflammatory process, depending on the composition of circulating immune system cells, the level of proinflammatory cytokines and complement activity, which in turn, it affects the course and speed of the inflammatory process, as well as the effectiveness of protective mechanisms. Currently, cellular integrative markers of systemic immune inflammation, such as neutrophil-lymphocytic, plateletlymphocytic, and systemic immune inflammation index, are becoming increasingly common in clinical trials. Coefficients are widely used in humane medicine as an independent predictor of the systemic inflammatory response, determining the severity of diseases. In this regard, it seems relevant to analyze the diagnostic significance of indices in veterinary medicine when assessing the systemic response to inflammation of various types of tissues. The purpose of the study – to conduct a comparative assessment of leukocyte indices in inflammation of glandular and connective tissue in animals with a lymphocytic blood profile. The object of research is cattle, divided into groups depending on the type of tissue with an inflammatory process: 1st - clinically healthy; 2d - with inflammation of glandular tissue; 3d - with inflammation of connective tissue. As a result of the comparative analysis, we found that the systemic inflammatory response of glandular tissue is more pronounced in animals with a lymphocytic blood profile compared to connective tissue, and the development of complications in the form of a cytokine cascade is most likely with inflammation of this type of tissue. The calculation of hematological indices in animals is informative for assessing the pathophysiological aspects of inflammation, due to its ease of calculation, it can also be recommended for use in clinical practice in order to assess the degree of the inflammatory process and determine the prognosis of diseases.

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