Ceruloplasmin as a diagnostic marker of malignancy in animal’s mammary gland tumors
Abstract
Breast cancer - is a malignant neoplasm, proliferating from tubular epithelium and mammary gland parenchyma. There is a lack of absolute data in etiology factors. Clinical features of mammary gland neoplasia are very variable, from aggressive to indolent. Nowadays, there are no markers in veterinary medicine for the presence, distribution, and features of biological behavior. In this study, we are going to evaluate one of the serum proteins as breast cancer malignancy marker and defy elucidate the connection between the activity of the antioxidant system and oxidative stress produced by rapid growth of neoplastic tissues. Due to the obtained information, we can propose a method of non-invasive estimation. This indirect method will help veterinary doctors to obtain specific information about malignancy status, prognosis and operation risks. We studied serum of 20 companion dogs, different breeds and one age group (7-13 years). The first group (n=15) - had breast cancer, without comorbidities, control group (n=5) -consisted of healthy dogs. In these papers, we observe a correlation between serum ceruloplasmin and neoplasia malignancy in companion animals. We defined the connection between malignancy state of breast cancer affected mammary gland and serum ceruloplasmin concentration.
About the Authors
A. . Letunovskaja
St. Petersburg State Academy of Veterinary Medicine; Almazov National Medical Research Centre; Herzen State Pedagogical University of Russia
Russian Federation
Russian Federation
P. . Babich
Herzen State Pedagogical University of Russia
Russian Federation
Russian Federation
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Review
For citations:
Letunovskaja A., Babich P. Ceruloplasmin as a diagnostic marker of malignancy in animal’s mammary gland tumors. International Journal of Veterinary Medicine. 2019;(1):149-153. (In Russ.)
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