Effect of hypoxen on histological changes in the liver of white rats using a model of toxic hepatitis

Any disorders in the body caused by infectious effects, the use of drugs, vaccines, etc. accompanied by a violation of the liver. The highest hepatotoxic effect is possessed by various xenobiotics that enter the body of animals with food or water. Therefore, an urgent direction of modern research is the search for means that increase the liver's resistance to pathological influences, enhancing its detoxifying functions. To achieve the goal of resolution, the following tasks were set: to establish the effect of hypoxene on the average daily gain of rats against the background of experimental toxic hepatitis, to assess the hepatoprotective effect of hypoxene on the basis of histological changes in the liver of animals, to compare the pharmacological effect of hypoxene with heptrane. When studying the hepatoprotective properties of hypoxene, a model of experimental toxic hepatitis in white rats was used. The effectiveness of the drugs was assessed by the clinical state of white rats and histological changes in the liver. Acute toxic hepatitis was caused by intraperitoneal injection of carbon tetrachloride in vaseline oil to white rats at the rate of 0.4 ml per 100 g of body weight for 3 days once. Microscopic examination of the liver in animals revealed a violation of the cytoplasmic membranes of hepatocytes, which was accompanied by fatty degeneration of liver cells and the development of hepatosis. The use of hypoxene stopped this pathological process. After using the drug, the animals' body weight increased. When analyzing histosections of the liver, no signs of fatty degeneration were found. Thus, hypoxene can be used in animals as a hepatoprotective agent at a dose of 50.0 mg / kg of body weight.

white rats, carbon tetrachloride, hypoxen, geptran, liver

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