Clinical trials of the drug in pigs with mycoplasmosis

Abstract

The purpose of our research was to study the effectiveness of the antibiotic based on doxycycline and tylosin in pigs with mycoplasmosis. For this 3 groups of 50 piglets of the growing group with a pre-established diagnosis mycoplasmosis were formed. The drug Doctil was tested in powder form. One gram of the preparation contains 100 mg of doxycycline hydrochloride and 100 mg of tylosin tartrate as active substances. The studied drug was administered orally according to the technical specifications of the manufacturer at a dose of 1 g per 1 liter of water for drinking which corresponds to 100 mg of the drug (10 mg of doxycycline and 10 mg of tylosin) per 1 kg of animal body weight once a day. For animals of the first group the drug was administered for 3 days, for animals of the second group the drug was administered for 5 days. Animals of the 3rd group served as a control - they were orally administered a third-party drug based on doxycycline according to the instructions at a dose of 10 mg / kg doxycycline once a day for 5 days. Diagnosis of mycoplasmosis was performed before the start of the experiments and also after 10 and 30 days after the end. As a result of research the following conclusion can be made. The use of an antibiotic based on doxycycline and tylosin at a dose of 10 mg / kg for each active substance once a day for 5 days is the most effective way to treat piglets suffering from mycoplasmosis as evidenced by the negative results of the polymerase chain reaction to mycoplasmosis in all piglets of the second experimental groups 30 days after the end of the study.