Residual amounts of ciprofloxacin in the organism of chicken after oral intake of cyvetin

Studies to determine the residual amounts of ciprofloxacin in the body of chickens. In the first experiment determined the residual amount of ciprofloxacin after oral administration civatin with drinking water. The studies were conducted on 15 healthy chickens of cross-Heisex brown at the age of 36-40 days and weighing 1-1.1 kg. the Drug was administered orally,200 mg/l of water for 10 days. The poultry slaughter and sampling for the study were carried out 24, 48, 72, 96 and 120 hours after the cessation of drug evaporation. The objects of study were serum, heart, lungs, intestinal wall, liver, skeletal muscles, muscle stomach and kidneys. The second experiment was carried out in a similar way, but ciprofloxacin was given orally in a mixture with feed in a free access concentration of 200 mg/kg of feed for 10 days. The content of ciprofloxacin was determined by microbiological diffusion in agar using test microbe Bacillus subtilis ATCC 6633. In chickens killed after 24 hours, ciprofloxacin was recorded in all studied tissues, organs and biological fluids at concentrations ranging from 0.26 to 0.49 pg/g (pg/ml). In chickens killed after 48 hours, the drug was found in about the same concentrations as in the previous time period. The exception was the lungs, in which ciprofloxacin was not detected. After 72 hours, ciprofloxacin was found in the muscle stomach (0.28 pg/g), heart (0.58 pg/g) and liver (0.52 pg/g). In chickens killed after 96 and 120 hours after the end of the drug, ciprofloxacin was not found. Studies have shown that the oral administration of ciprofloxacin to chickens for 10 days with food and water in concentrations of 200 mg / kg of feed and 200 mg / l of water, the drug is completely removed from the body after 96 h after its use.

фторхинолоны, ципрофлоксацин, остаточные количества, пероральное введение, цыплята, fluoroquinolones, ciprofloxacin, residues, oral intake, chickens

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