Antioxidant activity of lacrimal fluid during post-carotid period in experimental animals

The dogs and cats who have transferred the general anesthesia have a widespread ophthalmologic complication called by a postoperative erosion of a cornea. When developing a disease the adhesion of a tear film and epithelium of a cornea is broken that leads to a recurrence of disease and developing of pathologies in secretaries of a tear film, especially lipid layer. Often, development of a chronic form of the KCS, causing irreversible structural and functional changes of a conjunctiva and cornea in a anterior sigment. We decided to carry out scientific work on a research of a postoperative erosion of a cornea of animals (rabbits) with use of experimental model for establishment of correlation between development of an erosion of a cornea and change of biochemical structure of a tear. Carried out by us before the research have shown change of quantitative and qualitative characteristics of plaintive liquid during the postoperative period at pets. It is shown that development of complications isn't connected with irreversible or long-term violations of secretion of a tear, however, is followed by decrease in stability of a tear film and also growth of the general protein of a tear and falling of the general antioxidant activity of a tear that is caused by effect of low-molecular antioxidants that leads to development of the KCS. In the work the dependence between the general anesthesia and development of a chronic form of the KCS in experimental animals (rabbits) is shown. It is established that the general anesthesia exerts impact on indicators of stability of a tear film, reducing its value twice. At all experimental animals decrease in antioxidant activity of plaintive liquid, and restoration of it is values only in 24 hours, with a complete recovery of indicators by 30-th day of observation is established. Further we plan to study general proteins of antioxidant protection: superoxide dismutase, glutathione peroxidase, glutathiones-s-transferase, glutation reductase. The further research is necessary. [3,4]

общая анестезия, эрозия роговицы, слезопродукция, стабильность слезной пленки, общая антиоксидантная активность слезы, General anesthesia, corneal erosion, tear production, tear film stability, General antioxidant activity of tears

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