Assessment of morphological changes in internal organs in the treatment of Aleutian mink disease with Alloferon

Abstract

Nowdays, viral plasmocytosis of mink is widespread all over the world, due to the lack of effective treatments. A key role in the outcome of the disease is often played by kidney damage associated with the development of glomerulonephritis as a result of hypergammaglobulinemia. It is for this reason that the problem of finding a remedy for the treatment and prevention of Aleutian mink disease becomes urgent. The studies were carried out on mink of the sapphire breed at the age of 30 to 40 days in patients with viral plasmocytosis, confirmed by molecular genetic analysis. The experimental and control groups consisted of 20 animals each. The minks of the experimental group were injected subcutaneously twice with an interval of 6 days with alloferon at a dose of 0.5 mg per head, and the minks of the control group were injected with saline solution (NaCl 0.9%) in the same volume and multiplicity. During the study, records of fallen minks were kept. At the end of the experiment, histological studies of internal organs were carried out. The conducted experience showed that the use of alloferon led to a reduction in mortality, as well as a several-fold decrease in the intensity of plasmocytic infiltration of organs and tissues in experimental minks.