Concentrations of Cypor levels in various pathologies of the gastrointestinal tract

Abstract

Medicines make up the majority of xenobiotics, and understanding the processes of pharmaco- and toxicokinetics is prevailing. Also, the question of the influence of the endogenous environment on the biotransformation of drugs, which changes depending on the stage and form of development of all diseases of both infectious and noninfectious etiology, remains open in the literature. The main objective of this study is to study the effect of exogenous cytochrome administration on CYPOR levels in various gastrointestinal pathologies. Five groups of laboratory rats were formed for the study (the studies were approved by the LEC at the FSBEI HE SPbGUVM, protocol No. 2, dated 04/20/2025), weighing 180-195 g, of both sexes, 10 heads per group (males and females were separately). As a result of the studies, we concluded that no reliable differences were found between males and females. All values were within the reference intervals. In induced liver pathologies in experimental animals, an increase in CYPOR levels was observed, which is associated with an increase in endogenous intoxication and increased expression of cytochrome in response to this intoxication, which, within the framework of compensatory mechanisms, also causes increased induction of CYPOR. When induced gastrointestinal pathologies, an insignificant increase in CYPOR was observed, since these pathologies, despite the point of expression of cytochrome, occur without its participation. The introduction of exogenous cytochrome in pathologies significantly increased CYPOR levels. Thus, the results of the study confirm that the introduction of exogenous cytochrome can stimulate CYPOR biosynthesis, especially in liver pathologies, which opens up prospects for further research in the field of pharmacotherapy of liver diseases using cytochromes and CYPOR regulation.