Biochemical parameters of the blood serum of white rats under the combined effect of fusariotoxins

Fusarium fungi are widely distributed in nature and produce the most toxic mycotoxins: T-2 toxin, diacetoxyscirpenol, nivalenol, deoxynivalenol, zearalenone, fumonisins, and moniliformin. Although fusariotoxins are commonly present in food and feed, their combined effects are still poorly understood. However, their possible interactions can potentially lead to antagonistic, additive, or synergistic effects. The purpose of this study was to evaluate the biochemical parameters of the blood serum of white rats under the combined effect of fumagillin (T-2 toxin, deoxynivalenol, zearalenone, fumonisin B1). The experiment was conducted on 60 white rats (weighing 119-125 g at the beginning of the experiment), divided into 10 groups based on the principle of analogues. The first group was a biological control, the second received a feed containing T–2 toxin at a dose of 0.1 mg/kg (at the MPC level), the third received a feed containing fumonisin B1 at a dose of 5.0 mg/kg (at the MPC level), the fourth received a feed containing deoxynivalenol at a dose of 1.0 mg/kg (at the MPC level), the fifth group is a feed containing zearalenone at a dose of 1 mg/kg (at the MPC level), the sixth is a feed containing a mixture of mycotoxins two times lower than the MPC), the seventh is a feed containing a mixture of mycotoxins 25% lower than the MPC), the eighth is a feed containing a mixture of mycotoxins in within the maximum permissible concentration), the ninth is a feed containing a mixture of mycotoxins 25% higher than the maximum permissible concentration), the tenth is a feed containing a mixture of mycotoxins 50% higher than the maximum permissible concentration). The combination of deoxynivalenol, T-2 toxin, zearalenone, and fumonisin B1 reduces the content of protein, triglycerides, and glucose, and increases the content of bilirubin, the activity of aminotransferases, alkaline phosphatase, and gammaglutamyltransferase.

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