Toxicological assessment of carbohydrate-vitamin-mineral concentrate «lizunets salt» (lacto elite) on white rats

Abstract

The aim of this work is to give a Toxicological assessment of the newly developed carbohydrate - vitamin - mineral concentrate «Lizunets salt» (lacto Elite), intended for dairy cows. To determine acute toxicity, four groups of white rats were formulated, each with a live weight of 190-200 g of 8 heads, which were orally given the drug in different doses. To determine the cumulative properties, two groups of white rats with 6 heads each were formed, which were given the drug for 14 days, starting with a dose of 0.8 g/kg, which was increased 1.5 times every 4 days. At the same time in experimental animals studied the clinical picture, behavioral reactions, take into account the growth of live weight. According to the results of the study, it was found that with a single administration of carbohydrate-vitamin-mineral concentrate «Lizunets salt» (lacto Elite) in animals there was shortness of breath, lack of appetite, refusal of food, but after 2-3 hours they returned to their original state. According to the existing methods, it was not possible to calculate the average dose as in the experimental groups of animals there was no death, so for further studies the maximum administered dose was used. In determining the cumulative properties of the drug on the 21st day of administration at a daily dose of 6.07 g / kg in animals there was General oppression of the body, frequent urination, diarrhea, tousled coat, but after 7-8 hours, these signs disappeared. In this connection, the cumulation coefficient was 8.31, that the substance has a weakly expressed cumulation.